The Mutation Of A Single Gene Dramatically Increases The Chances Of Contracting Cancer
The mutations of specific mismatch repair (MMR) genes including but not limited to MLH1, MSH2, MSH6, PMS2, and EPCAM-TACSTD1 deletions are responsible for Lynch syndrome. These genes work in repairing mistakes made when DNA is copied in preparation for cell division. The defects in the genes disallow repair of DNA mistakes and as cells divide, errors stack and uncontrollable cell growth may result in cancer.
Confronting The Risk
Having no gender, ethnic or cultural preferences, Lynch syndrome targets families, predisposing them to cancer at a younger than average age. Children of a Lynch syndrome parent possess a 50% risk of acquiring a mutation. During their lifetimes, those diagnosed face up to an 85% risk of contracting colon cancer and, as well, women have up to a 65% risk of contracting endometrial cancers. An increased risk exists of contracting a number of other cancers including those of the stomach, pancreas, kidney/ureter tract, hepatobiliary tract, gastric tract, prostate, ovaries, gall bladder duct, brain, small intestine, breast and the skin.
In Australia alone, tens of thousands of people are believed to be affected by the Lynch syndrome. Less than five percent (5%) are currently diagnosed. Lynch syndrome is not a rare condition but an extremely underdiagnosed condition in which the cancers it creates are often quite preventable.
Lives Can Be Saved Through Awareness And Testing
Despite the odds, immense hope exists; thanks to modern technology and the passionate and diligent efforts of dedicated researchers and medical professionals. Though no cure has yet been discovered, through genetic testing, the risk for cancer in families can be identified. By exercising preventative measures (early diagnosis, surveillance and treatment), enhanced quality of life and longevity can be achieved and individuals and families can be protected from cancer.
PROTECTING OUR FAMILIES AND OURSELVES
First Line of Defense
THE FAMILY HISTORY
Lynch syndrome is inherited through families. The first step of diagnosis of Lynch syndrome, in order to obtain provision of early and potentially life saving prevention measures, is by researching and documenting a comprehensive family history to present to one’s general practioner for assessment.
Second Line of Defense
The only known method of accurately diagnosing Lynch syndrome is through genetic testing, the closest thing to a cure which is known today. If the family medical history indicates three family members, two of which are directly related to a third, and who each sustained Lynch cancers, genetic testing should be discussed with one’s GP.
Third Line of Defense
Once Lynch syndrome has been diagnosed, a highly targeted screening and medical management program is essential and may be lifesaving. During routine surveillance screening, tumors may be discovered and are more easily removed or treated before becoming life threatening.
Our Melbourne Living With Lynch Syndrome event is filling fast. Our guest speakers so far include; Prof Finlay Macrae presenting on latest Australian research and the CaPP3 study, Associate Prof Gregor Brown on advances in colon cancer screening and Dr Kym Reid a review of preventative surgical options for women with Lynch syndrome-risks, benefits, future implications on health.
Saturday, 22 November, 2014.
Registration form for Melbourne Living with Lynch Syndrome
Lynch Syndrome Australia will be conducting an online survey soon. Please check back for more details.
KNOWLEDGE IS POWER
Click on the link above to see how these medical professionals are improving the awareness and understanding of Lynch syndrome.
As a Healthcare professional, I am delighted to support Lynch Syndrome Australia’s Knowledge is Power campaign and am committed to helping to improve awareness of Lynch syndrome, an hereditary condition which exposes families to an extreme high risk of contracting multiple aggressive cancers.
Name – Professor Robyn Ward
Occupation – Head of the Adult Cancer Program Lowy Cancer Research Centre
Location – Prince of Wales Clinical School, UNSW
Name – Dr Daniel Buchanan
Occupation – Senior Research Fellow
Location – Department of Pathology and Centre for Epidemiology and Biostatistics, University of Melbourne
Name –Dr David G. Hewett, Associate Professor & Director, Medical Leadership Program
Occupation – Gastroenterologist and Therapeutic Colonscopist
Location – University of Queensland School of Medicine
Name –Dr Kathy Tucker
Occupation – Geneticist
Location – Prince of Wales and St George, Hereditary Cancer Clinic
Name –Dr Rachel Susman
Occupation – Clinical Geneticist
Location – Genetic Health Queensland, Royal Women’s Hospital
Name –Dr Michael Gattas
Occupation – Clinical Geneticist
Location – Genetic Health Queensland & Brisbane Genetics, Wesley Medical Centre
Name –Professor Andreas Obermair
Occupation – Gynaecological Oncologist
Location –Royal Brisbane Women's Hospital & Greenslopes Private Hospital
Name –Jan Wakeling
Occupation – Associate Genetic Counsellor/Coordinator
Location –QLD Familial Cancer Registry, Royal Women's and Children's Hospital - Genetic Health QLD
Name – Dr Rachel Susman
Occupation – Senior Genetic Counsellor
Location –Royal Women's and Children's Hospital - Genetic Health QLD
Name –Professor Finlay Macrae
Occupation – Head, Colorectal Medicine & Genetics
Location –Royal Melbourne Hospital
KNOWLEDGE IS POWER - PRESS RELEASE
Our primary mission is to serve our Australian communities by focusing on providing support for individuals afflicted with Lynch Syndrome, creating public awareness of the syndrome, educating members of the public, outreach to medical professionals, in person, by mail, phone and through exhibiting at medical conferences
We will offer complimentary speaking services to organisations and institutions and provide support for Lynch Syndrome research endeavour.
What is Lynch Syndrome?
Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC) predisposes individuals to an approximate 80% chance of contracting colorectal cancer during one's lifetime as well as an up to 60% chance of contracting endometrial cancer.
Diagnosed individuals possess a higher than average risk of contracting various cancers of the gastrointestinal organs, cancers of the abdominal area, the ovaries, the esophaegus, the bladder, the ureter, the kidneys, the liver, the gallbladder duct, the pancreas, the prostate, the skin and the brain.
Because Lynch syndrome is hereditary, a 50% chance exists that a person will pass it down to one's children. Lynch syndrome does not skip generations.
Lynch syndrome is the result of an inherited genetic defect mostly involving the MLH1, MSH2, MSH6 and PMS2 genes. Other less common mutated genes involved with Lynch syndrome exist but the most common are the MLH1 and the MSH2.